My maternal grandmother, née Linda Preston, traveled as a singer with comedian Gene Sheldon in 1941. Unfortunately, it seems her tour with him was cut short when her brother, my Uncle Peter, took a curve too fast while driving her and ran the car into a tree. I remember Grandma told me her leg was broken, and got infected. She told me she begged the doctors in the hospital to save her leg rather than amputate it, and they gave her Sulfa drugs — brand new at the time — to kill the infection. They worked, mostly, but she was prone to getting infections in that leg in her old age.